Select a protein that has biomedical or health relevance
Instructions: Select a protein that has biomedical or health relevance, and make sure that the PDB coordinates are available for the selected protein. A good source is “Molecule of the Month” posted
Select a protein that has biomedical or health relevance,
Select a protein that has biomedical or health relevance, and make sure that the PDB coordinates are available for the selected protein.
A good source is “Molecule of the Month” posted in the Protein Data Bank (PDB) site.
In this case, I select Titin [Homo Sapiens human]
The protein should have at least 100 amino acids.
I have also attached the instructions!
More Details:
Due to the characteristics of structure determination methods, most entries do not include coordinates for every single atom in the identified molecule.
In some cases, the experimental method may not observe certain atoms.
For example, flexible regions and hydrogen atoms are not observe d in X-ray
crystallographic experiments, and therefore, are not include d in the PDB coordinate
files. In other cases, only a portion of the molecule may be included in the PDB entry.
For instance, in X-ray crystallographic structures of symmetrical molecules, the PDB
entry often includes only one subunit of the complex, and coordinates for the full
biological assembly need to be calculate d from the subunit coordinates.
When searching the PDB archive, it is important to consider what parts of a structure are include d in each particular entry.
Recombinant proteins provided important breakthroughs in biomedical biotechnology. They are not only us ed in biomedical research but also in treatment, as drugs.
The first recombinant protein use d in treatment was recombinant human insulin in 1982. The recombinant protein industry has rapidly grown.
To date, more than 130 recombinant proteins are approve d by the US FDA for clinical use. However, more than 170 recombinant proteins are produced and used in medicine worldwide.